Dr. Guoping Zhou is a distinguished researcher recognized for seminal contributions to structural biology, biophysics, and medicinal chemistry. His research focuses on elucidating protein–protein, protein–DNA, and protein–drug interactions using solution NMR spectroscopy, molecular modeling, and bioinformatics. He has advanced the understanding of protein misfolding mechanisms, polysialyltransferase function, and neural cell adhesion molecule (NCAM) polysialylation, providing structural insights with translational relevance to drug discovery. A notable contribution is the integration of Wenxiang diagrams with NMR data to interpret complex biomolecular interactions. His work includes NMR-determined structures deposited in the Protein Data Bank and influential studies published in high-impact journals across biochemistry, structural biology, and medicinal chemistry. With 4,789 citations, an h-index of 31, and an i10-index of 42, his scholarly output reflects sustained impact and leadership in advancing molecular-level understanding of biological systems through innovative structural and computational approaches.